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Ly-49H Monoclonal Antibody (3D10), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5886-95
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Beskrivelse
The MAb 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783). Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of MAb 3D10 to cell cultures induces lysis of target cells.
Ly-49H Monoclonal antibody specifically detects Ly-49H in Mouse samples. It is validated for Flow Cytometry, Functional Assay, Immunoprecipitation
Tekniske data
| Ly-49H | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Q60682 | |
| Mouse | |
| 10 mg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG1 κ |
| Flow Cytometry, Functional Assay, Immunoprecipitation | |
| 3D10 | |
| Unconjugated | |
| Klra8 | |
| Cmv1; Cmv-1; cytomegalovirus resistance 1; killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u<129>; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H | |
| Affinity chromatography | |
| RUO | |
| 16639 | |
| 4° C | |
| Liquid |
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