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Tocris Bioscience™ LY 404187
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Artikelnummer. 18791348
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50 mg
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18791348 10 mg
18750128 50 mg
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Artikelnummer. 18791348 Leverandør Tocris Bioscience™ Leverandørnr. 5297/10

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Beskrivelse

Selective AMPA receptor positive allosteric modulator

LY 404187 is a selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CAS 211311-95-4
Mængde 10 mg
Mål AMPA Receptor Modulators
Molekylær formel C19H22N2O2S
Formel vægt 342.46
Renhed >98%
Produkttitel
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