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Tocris Bioscience™ LY 2033298
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Artikelnummer. 18785636
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5 mg
25 mg
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Artikelnummer. Mængde
18785636 5 mg
18729376 25 mg
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Artikelnummer. 18785636 Leverandør Tocris Bioscience™ Leverandørnr. 7027/5

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Beskrivelse

Selective positive allosteric modulator of M4 receptors.

LY 2033298 is a selective positive allosteric modulator of M4 receptor (KB = 200 nM, α = 35); increases the potency of acetylcholine by 40-fold. Exhibits no effect at hM1/3/5 receptors and a small effect at hM2 (KB = 1 μM α = 3.7). Potentiates other full and partial orthosteric agonists, including Carbachol, Oxotremorine-M, and McN-A343 . Does not affect binding of antagonist NMS. Active in vivo. Antipsychotic.

α indicates the degree of allosteric enhancement when both orthosteric and allosteric sites are occupied (derived from the allosteric ternary complex model).

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
CAS 886047-13-8
Mængde 5 mg
Molekylær formel C13H14ClN3O2S
Renhed 98%
Produkttitel
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