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  5. Tocris Bioscience™ LM11A 31 dihydrochloride

Tocris Bioscience™ LM11A 31 dihydrochloride
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Artikelnummer. 18767048
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18767048 50 mg
18721468 10 mg
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Artikelnummer. 18767048 Leverandør Tocris Bioscience™ Leverandørnr. 5046/50

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Beskrivelse

Nonpeptide p75NTR ligand; neuroprotective

LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC50 = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.
TRUSTED_SUSTAINABILITY

Tekniske data

Renhed 95%
Molekylær formel (2 S,3 S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
CAS 1243259-19-9
Indhold og opbevaring Desiccate at RT
Mængde 50 mg
Produkttype LM11A 31 dihydrochloride
Molekylvægt (g/mol) M.W. (Observed): 316.27
Inhibitorer LM11A 31 dihydrochloride

For Research Use Only

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