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Tocris Bioscience™ LL-K9-3
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Artikelnummer. 18766195
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5 mg
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18766195 5 mg
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Artikelnummer. 18766195 Leverandør Tocris Bioscience™ Leverandørnr. 7813/5

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Beskrivelse

Selective HyT-based degrader of the CDK9-cyclin T1 complex

LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC50 values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.
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Tekniske data

Kemisk navn eller materiale N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1 R,2 S,5 R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide
CAS 2809353-52-2
Mængde 5 mg
Mål Active Degraders
Molekylær formel C31H49N5O6S3
Renhed 0.98
Produkttitel
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