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Lestaurtinib, MedChemExpress

Artikelnummer. 16490578
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Mængde:
5 mg
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Artikelnummer. Mængde
16490578 5 mg
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Artikelnummer. 16490578 Leverandør Medchem Express Leverandørnr. HY50867

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Beskrivelse

MedChemExpress Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Tekniske data

Kemisk navn eller materiale Lestaurtinib
CAS 111358-88-4
Farve White
Renhedsgrad noter Research
Molekylær formel C26H21N3O4
Mængde 5 mg
Synonym CEP-701 KT-5555
Opløselighedsinformation DMSO : 50 mg/mL (113.78 mM; Need ultrasonic)
SMIL O=C(NC1)C2=C1C3=C(C4=C52)N(C6=C3C=CC=C6)[C@@]([C@@](O)(CO)C7)(C)O[C@H]7N4C8=C5C=CC=C8
Molekylvægt (g/mol) 439.46
Formel vægt 439.46
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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