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Tocris Bioscience™ LEI 401
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Artikelnummer. 18795906
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Mængde:
10 mg
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Artikelnummer. Mængde
18795906 10 mg
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Artikelnummer. 18795906 Leverandør Tocris Bioscience™ Leverandørnr. 7407/10

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Beskrivelse

High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC50 for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line in vitro. It also reduces anandamide levels in mouse brain in vivo and impairs fear extinction. LEI 701 is CNS penetrant and cell-permeable.
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Tekniske data

Kemisk navn eller materiale N-(Cyclopropylmethyl)-6-[(3 S)-3-hydroxy-1-pyrrolidinyl]-2-[(3 S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
CAS 2393840-15-6
Mængde 10 mg
Mål Phospholipase Inhibitors
Molekylær formel C24H31N5O2
Renhed 0.98
Produkttitel
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