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Tocris Bioscience™ LDN 193189 dihydrochloride
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Artikelnummer. 18707806
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18707806 10 mg
18787766 50 mg
18075802 1 mg
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Artikelnummer. 18707806 Leverandør Tocris Bioscience™ Leverandørnr. 6053/10

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2201.84 DKK valid until 2026-06-30
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Beskrivelse

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).

LDN 193189 synthesized to Ancillary Material Grade also available.

For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
CAS 1435934-00-1
Synonym 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Mængde 10 mg
Opløselighed Soluble to 50mM in water and to 20mM in DMSO
Mål BMP and Other Activin Receptor Inhibitors
Molekylær formel C25H22N60.2 HCl
Formel vægt 479.4
Fysisk form Solid
Farve Orange
Produkttype Bioactive Small Molecule
Renhed 98%
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For Research Use Only.

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