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Tocris Bioscience™ LC 2
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Artikelnummer. 18776556
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Mængde:
2 mg
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18776556 2 mg
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Artikelnummer. 18776556 Leverandør Tocris Bioscience™ Leverandørnr. 7420/2

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Beskrivelse

Selective KRAS PROTAC™

LC 2 is a mutant-selective PROTAC™ Degrader of KRAS, comprising a ligand for the von Hippel Lindau E3 ligase joined to the KRAS inhibitor MRTX849. LC 2 induces selective degradation of KRASG12C in cancer cell lines without inducing degradation of any other mutants (DC50 = 0.25-0.76 μM), leading to suppression of MAPK signaling and modulation of ERK signaling in both homozygous and heterozygous KRASG12C cancer cell lines. LC 2 inhibits phosphorylation of ERK in SW1573 cell lines.

Negative control LC 2 Epimer (Cat. No. 7421) also available.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2 S,4 R)-1-(-2-(3-(3-(-2-(((7-(8-Chloronaphthalen-1-yl)-4-(-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m)
CAS 2502156-03-6
Mængde 2 mg
Mål Active Degraders
Molekylær formel C59H71ClFN11O7S
Renhed 0.95
Produkttitel
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