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Invitrogen™ LATS1 Recombinant Human Protein

LATS1 is a putative serine/threonine kinase. Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

3660.00 DKK - 55700.00 DKK

Specifications

For Use With (Application) Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
Formulation 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
Molecular Weight (g/mol) 89.4kDa
Storage Requirements Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
Gene Alias WARTS, wts
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15468993
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Invitrogen™
PV6361
10μg
3660.00 DKK
10µg
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Estimated Shipment: 12-04-2024
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15478993
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Invitrogen™
PV6362
100μg
12470.00 DKK
100µg
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Estimated Shipment: 11-04-2024
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15488993
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Invitrogen™
PV6363
1mg
55700.00 DKK
1mg
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Estimated Shipment: 11-04-2024
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Description

Description

LATS1 localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
89.4kDa
WARTS, wts
Human
GST Tag
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
aa 589-end
Recombinant
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