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Invitrogen™ Human LATS1, GST Tag Recombinant Protein

Artikelnummer. 15468993
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
1mg
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Artikelnummer. 15468993

Brand: Invitrogen™ PV6361

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. , Validated in LanthaScreen™ Kinase Binding Assay, Protocols available for simple use and optimized performance, Multiple pack sizes available for convenient use Protein Form: Recombinant The gene accession number for LATS1 is NP_004681.1.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer O95835
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 9113
Molekylvægt (g/mol) 89.4 kDa
Navn Human LATS1, GST Tag
Mængde 10 μg
Gene Alias AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Fælles navn LATS1
Protein længde 589-end
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Udtrykssystem Baculovirus
Form Liquid
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