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Invitrogen™ LATS1 Recombinant Human Protein
LATS1 is a putative serine/threonine kinase. Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Brand: Invitrogen™ PV6361
Additional Details : Weight : 0.01000kg
Description
LATS1 localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Specifications
| Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation | |
| 89.4kDa | |
| Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. | |
| aa 589-end | |
| Recombinant |
| 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol | |
| 10μg | |
| WARTS, wts | |
| Human | |
| GST Tag |