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Tocris Bioscience™ Laropiprant
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Artikelnummer. 18736566
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18736566 10 mg
18718276 50 mg
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Artikelnummer. 18736566 Leverandør Tocris Bioscience™ Leverandørnr. 7343/10

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Beskrivelse

Potent and selective prostaglandin D2 receptor antagonist

Laropiprant is a potent and selective prostaglandin D2 receptor antagonist (IC50 = 0.09 nM in washed platelets; Ki = 0.57). It exhibits selectivity for binding to PGD2 receptors over other prostanoid receptors (Ki values are ≥ 2.95 nM for TP, EP1, EP2, EP3, EP4, FP and IP). Laropiprant promotes coagulation of whole blood ex vivo and reduces bleeding time in mice in vivo. In a mouse model of intracerebral hemorrhage, Laropiprant reduces lesion volume and attenuates neurological deficit scores. The compound also reduces Niacin (Cat. No. 4106) induced vasodilation.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (3 R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid
CAS 571170-77-9
Mængde 10 mg
Mål Prostanoid Receptor Antagonists
Molekylær formel C21H19ClFNO4S
Renhed 0.98
Produkttitel
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