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STEMCELL Technologies Lapatinib​

Artikelnummer. 17130192
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Mængde:
10 mg
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Artikelnummer. Mængde
17130192 10 mg
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Artikelnummer. 17130192 Leverandør STEMCELL Technologies Leverandørnr. 73242

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Beskrivelse

Tyrosine kinase inhibitor; Inhibits EGFR and HER2

  • Lapatinib is a selective dual inhibitor of epidermal growth factor receptor (EGFR, ERBB1) and human epidermal growth factor receptor 2 (HER2, ERBB2), each with an IC50 of about 10 nM (Rusnak et al.) It binds reversibly, but with a very slow off-rate, to the ATP binding pocket in an inactive-like conformation, thus preventing autophosphorylation
  • Binding is very potent, with Ki values of 3 and 13 nM to EGFR and HER2 respectively (Wood et al.)
  • Induces apoptosis in cells overexpressing EGFR and/or HER2, and inhibits tumor growth in a mouse xenograft model (Xia et al.)

Tekniske data

CAS 231277-92-2
Synonym GSK 572016; GW 572016; Tyverb; GW2016
Mængde 10 mg
Molekylær formel C29H26ClFN4O4S
Renhed ≥98%
Produkttitel
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