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Tocris Bioscience™ KYP 2047
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Artikelnummer. 18788006
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18788006 25 mg
18765746 5 mg
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Artikelnummer. 18788006 Leverandør Tocris Bioscience™ Leverandørnr. 6272/25

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Beskrivelse

High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
CAS 796874-99-2
Mængde 25 mg
Molekylær formel C20H25N3O2
Formel vægt 339.44
Renhed 98%
Produkttitel
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