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Tocris Bioscience™ KYA 1797K
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Artikelnummer. 18799356
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5 mg
25 mg
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Artikelnummer. Mængde
18799356 25 mg
18084782 5 mg
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Artikelnummer. 18799356 Leverandør Tocris Bioscience™ Leverandørnr. 7002/25

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Beskrivelse

Wnt/β-catenin signaling inhibitor

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
CAS 1956356-56-1
Mængde 25 mg
Molekylær formel C17H11KN2O6S2
Renhed 98%
Produkttitel
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