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Invitrogen™ Human KIT [V559D], GST Tag Recombinant Protein

Artikelnummer. 17128735
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
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Artikelnummer. 17128735

Brand: Invitrogen™ A32867

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This KIT V559D recombinant human protein (544-end) was expressed in insect cells. KIT V559D recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Z'-LYTE™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic, Mutant The gene accession number for KIT [V559D] is NP_000213.1.

KIT receptor tyrosine kinase is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P10721
Koncentration See Label
Til brug med (applikation) Kinase Assay
Format Kit
Formulering 50mM tris HCl with 0.1mM PMSF, 0.25mM DTT, 0.1mM EDTA, 150mM NaCl, 10mM glutathione, 25% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 3815
Molekylvægt (g/mol) 75.3 kDa
Navn Human KIT [V559D], GST Tag
pH-område 7.5
Oprensningsmetode Purified
Mængde 100 μg
Opbevaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias KIT
Fælles navn KIT (V559D Mutant)
Gen symbol KIT
KinaseFamily PDGFR Kinase Family
Protein længde 544-end
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Sekvens 544-end
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Forsendelsestilstand Dry Ice
Udtrykssystem Insect cells
Protein form Recombinant, Active, Catalytic, Mutant
Form Liquid
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