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STEMCELL Technologies Kenpaullone

Artikelnummer. 17160122
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Mængde:
10 mg
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Artikelnummer. Mængde
17160122 10 mg
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Artikelnummer. 17160122 Leverandør STEMCELL Technologies Leverandørnr. 72782

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Beskrivelse

WNT pathway activator; Inhibits GSK3

  • Kenpaullone is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β; Bain et al.; Leclerc et al.; Zaharevitz et al.) It inhibits GSK-3β, Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p25, and lymphocyte kinase with IC50 values of 0.23, 0.4, 0.68, 0.85, and 0.47 μM, respectively (Bain et al.; Zaharevitz et al.)
  • Replaces Klf4 in the generation of induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) transduced with Oct4, Sox2, and c-Myc (Lyssiotis et al.)
  • Enhances neuronal differentiation in rat and human neural precursor cell cultures (Castelo-Branco et al.; Lange et al.)
  • Promotes survival of motor neurons derived from mouse embryonic stem (ES) cells and from Amyotrophic Lateral Sclerosis (ALS) patient iPS cells (Yang et al.)
  • Inhibits KLF4 expression and self-renewal in breast cancer stem cells in vitro (Yu et al.)

Tekniske data

CAS 142273-20-9
Synonym 9-Bromopaullone; NSC 664704
Mængde 10 mg
Molekylær formel C16H11BrN2O
Renhed ≥98%
Produkttitel
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