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Invitrogen™ KDM5B Monoclonal Antibody (CL1147)
GREENER_CHOICE

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA524627

Produktkode 15729280

  • 4245.00 DKK / 100µL

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Beskrivelse

Beskrivelse

Immunogen sequence: DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS E Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 91%. Binds to an epitope located within the peptide sequence SERWERVKKMRTPKK as determined by overlapping synthetic peptides.

KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
TRUSTED_SUSTAINABILITY
Tekniske data

Tekniske data

KDM5B
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9UGL1
KDM5B
Recombinant protein fragment of Human KDM5B (Product #RP-94108)
100 μL
Primary
Human
Antibody
IgG1
Western Blot
CL1147
Unconjugated
KDM5B
2010009J12Rik; 2210016I17Rik; AW556288; cancer/testis antigen 31; CT31; D1Ertd202e; Histone demethylase JARID1B; Jarid1b; jumonji, AT rich interactive domain 1B; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji, AT rich interactive domain 1B (RBP2-like); jumonji/ARID domain-containing protein 1B; KDM5B; Kiaa4034; lysine (K)-specific demethylase 5B; lysine demethylase 5B; lysine-specific demethylase 5B; mKIAA4034; PLU1; PLU-1; PPP1R98; protein phosphatase 1, regulatory subunit 98; PUT1; putative DNA/chromatin binding motif; putative DNA/chromatin binding motif 1; Rb-Bp2; RBBP2H1; RBBP2H1A; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A; RGD1565602
Mouse
Protein A
RUO
10765
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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