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Tocris Bioscience™ JQEZ5
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Artikelnummer. 18798486
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10 mg
50 mg
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Artikelnummer. Mængde
18798486 10 mg
18769686 50 mg
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Artikelnummer. 18798486 Leverandør Tocris Bioscience™ Leverandørnr. 6153/10

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Beskrivelse

Potent and selective SAM-competitive EZH2 inhibitor

JQEZ5 is a potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 11 nM). Selectively binds EZH2 over a panel of 22 methyltransferases. Reduces global level of the PRC2-associated mark H3K27me3 in K562 cells. Suppresses cell growth in CML cells. Inhibits colony formation of primary human CD34+ CML stem/ progenitor cells. Antitumor effects in vivo.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS 1913252-04-6
Mængde 10 mg
Molekylær formel C30H38N8O2
Renhed 98%
Produkttitel
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