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Tocris Bioscience™ JQAD1
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Artikelnummer. 18716426
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Mængde:
5 mg
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Artikelnummer. Mængde
18716426 5 mg
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Artikelnummer. 18716426 Leverandør Tocris Bioscience™ Leverandørnr. 7682/5

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Beskrivelse

Potent and selective EP300 Degrader

JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC™; DC50 ≤ 31.6 nM); comprises an EP300 inhibitor, A485 (Cat.No. 6387), joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis. JQAD1 suppresses tumors growth in NSG mice xenografted with Kelly cells. CRC and MYCN genes are downregulated in tumors treated with JQAD1. JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
CAS 2417097-18-6
Mængde 5 mg
Mål Active Degraders
Molekylær formel C48H52F4N6O9
Renhed 98%
Produkttitel
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