missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Proteinanalysereagenser
  4. Bioaktive små molekyler
  5. 30116125

Tocris Bioscience™ JPS016

Product Code. 30116125
Change view
Click to view available options
Mængde:
5 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Mængde
30116125 5 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 30116125 Supplier Tocris Bioscience™ Supplier No. 8083/5

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Selective class I HDAC Degrader (PROTAC™)

JSP016 is a selective Degrader (PROTAC™) and inhibitor of class I HDACs (DC50 values are 530 nM and 550 nM for HDAC3 and HDAC1; Dmax is 77%, 66% and 45% at HDAC1, 3 and 2; IC50 values are 380 nM, 570 nM and 820 nM at HDAC3, 1 and 2). Comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand. JPS016 treatment up- or down-regulates nearly 4000 differentially expressed genes, arrests cells at sub-G1 phase and promotes apoptosis in HCT116 cells.
TRUSTED_SUSTAINABILITY

Specifications

Kemisk navn eller materiale (2S,4R)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2669785-77-5
Mængde 5 mg
Mål Active Degraders
Molekylær formel C48H63N7O8S
Renhed 0.97
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.