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Tocris Bioscience™ JNJ 55511118
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Artikelnummer. 18719817
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25 mg
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18719817 25 mg
18718078 5 mg
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Artikelnummer. 18719817 Leverandør Tocris Bioscience™ Leverandørnr. 6278/25

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Beskrivelse

Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). Exhibits <50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS 2036081-86-2
Analyseprocentområde >98%
Mængde 25 mg
Molekylær formel C14H8ClF3N2O2
Formel vægt Observed MW: 328.67
Produkttitel
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