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Tocris Bioscience™ JNJ 1013
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Artikelnummer. 18084262
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5 mg
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18084262 5 mg
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Artikelnummer. 18084262 Leverandør Tocris Bioscience™ Leverandørnr. 8029/5

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Beskrivelse

Interleukin 1 Receptor Associated Kinase 1 (IRAK1) PROTAC™

JNJ 1013 is a potent interleukin 1 receptor associated kinase 1 (IRAK1) PROTAC™ Degrader (DC50 = 3 nM; Dmax = 96%). In ABC DLBCL cell lines with MyD88 L265P mutation, JNJ 1013 potently inhibits IRAK1 downstream signaling pathways, induces apoptosis, and shows strong anti-proliferative effects. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Tekniske data

Kemisk navn eller materiale N-(4-(4-(2-(((S)-1-((2S,4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)piperidin-1-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide
CAS 2597343-08-1
Mængde 5 mg
Mål Active Degraders
Molekylær formel C46H55N9O7S
Renhed 98%
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