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Tocris Bioscience™ JBJ-03-142-02
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Artikelnummer. 18768496
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Mængde:
10 mg
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18768496 10 mg
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Artikelnummer. 18768496 Leverandør Tocris Bioscience™ Leverandørnr. 6962/10

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Beskrivelse

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.
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Tekniske data

Kemisk navn eller materiale (4-Fluorophenyl)methyl N-[2-[(1-methyl-1 H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
CAS 2068806-31-3
Mængde 10 mg
Mål EGF Receptor Inhibitors
Molekylær formel C25H22FN7O3
Formel vægt 2323
Renhed 98%
Produkttitel
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