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STEMCELL Technologies JAK Inhibitor I

Artikelnummer. 17130312
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Mængde:
1 mg
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17130312 1 mg
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Artikelnummer. 17130312 Leverandør STEMCELL Technologies Leverandørnr. 74024

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Beskrivelse

JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3

  • Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain
  • This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.)
  • Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.)
  • Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.)

Tekniske data

CAS 457081-03-7
Synonym CMP 6; Janus-associated kinase inhibitor I;Pyridone 6
Mængde 1 mg
Molekylær formel C18H16FN3O
Renhed ≥98%
Produkttitel
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