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Tocris Bioscience™ Ivosidenib
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Artikelnummer. 18736926
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50 mg
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Artikelnummer. Mængde
18736926 10 mg
18798656 50 mg
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Artikelnummer. 18736926 Leverandør Tocris Bioscience™ Leverandørnr. 7761/10

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Beskrivelse

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.
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Tekniske data

Kemisk navn eller materiale (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
CAS 1448347-49-6
Mængde 10 mg
Mål Isocitrate Dehydrogenase 1/IDH1
Molekylær formel C28H22ClF3N6O3
Produkttitel
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