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Invitrogen™ IFN gamma Human ProQuantum Immunoassay Kit
Measure cytokine proteins with small sample consumption and high sensitvity on a qPCR instrument
Brand: Invitrogen™ A35576
5111.00 DKK valid until 2024-12-31
Use promo code "21989" to get your promotional price.
Additional Details : Weight : 0.22720kg
Description
IFN gamma (Interferon gamma,Type II interferon) is a macrophage activation factor,and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens,mitogens,Staphylococcus enterotoxin B,phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists,functionally,as a homodimer of approximately 45 kDa. On SDS-PAGE,IFN gamma appears as a combination of 25,20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity,tumor antiproliferative activity,induction of class I and II MHC,macrophage activation,and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II,and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2,FGF basic,EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.Specifications
P01579 | |
<0.01pg/mL | |
ProQuantum | |
Human | |
qPCR Instruments | |
IFG; IFI | |
FAM™ | |
RUO | |
-20°C | |
30 min. |
0.0128 – 5000pg/mL | |
Taqman™ Real-time PCR | |
Plasma, Serum, Supernatant | |
Cytokine protein quantitation | |
3458 | |
Assay Dilution Buffer<Br>Antibody-Conjugate A<Br>Antibody-Conjugate B<Br>Antibody-Conjugate Dilution Buffer<Br>Standard<Br>Master Mix<Br>Ligase | |
96 Tests | |
Serum, 2-5 μL; Supernatant, 2-5 μL; Plasma, 2-5 μL | |
Human | |
2 hr. |