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Tocris Bioscience™ Indinavir sulfate

Beskrivelse
Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.
Tekniske data
Tekniske data
| Kemisk navn eller materiale | 2,3,5-Trideoxy-N-[(1 S,2 R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]-5-[(2 S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate |
| CAS | 157810-81-6 |
| Mængde | 50 mg |
| Mål | HIV Protease Inhibitors |
| Molekylær formel | C36H47N5O4.H2SO4 |
| Renhed | 0.98 |
Produkttitel
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