IL-5 Rat anti-Human, Biotin, Clone: JES1-5A10, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 13-7059-85
Additional Details : Weight : 0.25000kg
Description: The JES1-5A10 antibody reacts with human interleukin-5 (IL-5), also known as BCDF-alpha and eosinophil differentiation factor (EDF). This 15-20 kDa cytokine is secreted by T cells and exists a homodimer. Applications Reported: JES1-5A10 has been reported for use in detection of human IL-5 by ELISA. Applications Tested: The JES1-5A10 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human Interleukin-5 (IL-5) in combination with the purified TRFK5 (14-7052) antibody for capture and recombit human IL-5 (14-8059) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 µg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 500 pg/mL - 4 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|Interleukin-5, EDF, IL-5, TRF, T-cell replacing factor, TRF, Eosinophil differentiation factor, B cell differentiation factor I|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.