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Tocris Bioscience™ Ibrutinib
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Artikelnummer. 18757926
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10 mg
50 mg
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18757926 10 mg
18716506 50 mg
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Artikelnummer. 18757926 Leverandør Tocris Bioscience™ Leverandørnr. 6813/10

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Beskrivelse

Potent and selective BTK inhibitor (IC50= 0.5 nM)

Ibrutinib is a potent and selective BTK inhibitor (IC50= 0.5 nM). Selective for BTK against a screening panel of kinase enzymes. Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively). Also inhibits ErbB4 (IC50 = 0.25-3.4 nM). Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells. Reduces clinical arthritis scores in a mouse model.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
CAS 936563-96-1
Synonym Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase
Mængde 10 mg
Molekylær formel C25H24N6O2
Formel vægt 440.5
Renhed 98%
Produkttitel
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