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Tocris Bioscience™ iBET-BD2
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Artikelnummer. 18719916
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50 mg
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Artikelnummer. Mængde
18719916 10 mg
18709756 50 mg
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Artikelnummer. 18719916 Leverandør Tocris Bioscience™ Leverandørnr. 7458/10

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Beskrivelse

Potent and selective pan-BD2 inhibitor; orally bioavailable

iBET-BD2 is a potent and selective pan-BD2 inhibitor (IC50 values are 49, 98, 214 and 264 nM for BRD4BD2, BRD3BD2, BRDTBD2 and BRD2BD2, respectively). iBET-BD2 is selective for BD2 over BD1 (IC50 values are 10965, 36317, 70558, and >50119 ?M for BRD2BD1, BRD3BD1, BRD4BD1, and BRDTBD1, respectively) in a time-resolved FRET (TR-FRET) assay. iBET-BD2 (1 μM) inhibits IFN-γ-induced protein expression of MHC class I in K562 cells. iBET-BD2 reduces the production of anti-KLH IgM antibodies in mice immunized with keyhole limpet hemocyanin (KLH). iBET-BD2 exhibits immunomodulatory activity. iBET-BD2 is orally bioavailable.
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Tekniske data

Kemisk navn eller materiale 4-(Acetylamino)-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1 S)-1-phenylethoxy]benzamide
CAS 2474876-09-8
Mængde 10 mg
Mål Bromodomain Inhibitors
Molekylær formel C23H27FN2O4
Renhed 0.98
Produkttitel
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