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Invitrogen™ Human ZIP1 Synthetic Peptide
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Mængde:
50 μg
Pakningsstørrelse:
50µg
Beskrivelse
ZIP1 Synthetic Peptide, PEP-1180, from Invitrogen.
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
Tekniske data
Tekniske data
| Gen-id (Entrez) | 27173 |
| Arter | Human |
| Oprensningsmetode | purified |
| Adgangsnummer | Q9NY26 |
| Fælles navn | Human ZIP1 |
| Koncentration | 200 μg/mL |
| Indhold og opbevaring | -20°C |
| Oversigt | Synthetic Peptide |
| Format | Liquid |
| Formulering | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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