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Invitrogen™ Human PHAP Synthetic Peptide
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Mængde:
50 μg
Pakningsstørrelse:
50µg
Beskrivelse
PHAP Synthetic Peptide, PEP-0143, from Invitrogen.
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
Tekniske data
Tekniske data
| Gen-id (Entrez) | 8125 |
| Arter | Human |
| Oprensningsmetode | purified |
| Adgangsnummer | P39687 |
| Fælles navn | Human PHAP |
| Koncentration | 200 μg/mL |
| Indhold og opbevaring | -20°C |
| Oversigt | Synthetic Peptide |
| Format | Liquid |
| Formulering | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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