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Gibco™ Human Oncostatin M (196 aa) Recombinant Protein, PeproTech®

Artikelnummer. p-7246141
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Mængde:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
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Artikelnummer. 17871413

Brand: Gibco™ 30010H100UG

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Descripción

Recombinant Protein

PeproTech's Recombinant Human Oncostatin M (196 a.a.) is a HEK293 cell-derived, 196 amino-acid length glycoprotein that has a calculated theoretical molecular weight of 22.2 kDa, but migrates at an apparent molecular weight of 32-34 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
TRUSTED_SUSTAINABILITY

Especificaciones

Adgangsnummer P13725
Til brug med (applikation) Functional Assay
Formulering protein with no preservative
Gen-id (Entrez) 5008
Molekylvægt (g/mol) 22.2 kDa
Navn Human Oncostatin M (196 aa)
Mængde 100 μg
Kilde HEK293 cells
Regulatorisk status RUO
Endotoksin koncentration <1 EU/ μg
Gene Alias MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
Fælles navn Oncostatin M
Gen symbol OSM
Biologisk aktivitet Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRR
Indhold og opbevaring -20°C
Udtrykssystem HEK293 cells
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 95% by SDS-PAGE gel and HPLC analyses.
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