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Gibco™ Human Noggin Recombinant Protein, PeproTech®

Artikelnummer. p-7246034
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Mængde:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
50 μg
500 μg
Pakningsstørrelse:
100µg
20µg
250µg
50µg
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Artikelnummer. 17840123

Brand: Gibco™ 12010C100UG

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5016.00 DKK valid until 2025-12-31
BEDSTE tilbudspris! Brug kampagnekoden "24071" for at få din tilbudspris.
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Beskrivelse

Recombinant Protein

120-10C-1MG will be provided as 2 x 500 μg (120-10C-500UG). Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer Q13253
Til brug med (applikation) Control, Bioactivity
Formulering Protein with no preservative
Gen-id (Entrez) 9241
Molekylvægt (g/mol) 46 kDa
Navn Human Noggin
Oprensningsmetode Purified
Mængde 100 μg
Kilde HEK293 cells
Opbevaringskrav -20°C
Regulatorisk status RUO
Endotoksin koncentration <1 EU/μg
Gene Alias NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A
Fælles navn Noggin
Gen symbol NOG
Biologisk aktivitet Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Produkttype Protein
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
Indhold og opbevaring -20°C
Aktivitet Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Udtrykssystem HEK293 cells
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 95% by SDS-PAGE gel and HPLC analyses.
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