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Gibco™ Human LIF, Animal-Free Recombinant Protein, PeproTech®

Artikelnummer. 17843373
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Mængde:
1 mg
100 μg
25 μg
500 μg
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Artikelnummer. 17843373

Brand: Gibco™ AF3000525UG

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Beskrivelse

Recombinant Protein

Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P15018
Til brug med (applikation) Functional Assay
Formulering protein with no preservative
Gen-id (Entrez) 3976
Molekylvægt (g/mol) 19.6 kDa
Navn Human LIF, Animal-Free
Mængde 25 μg
Kilde E. coli
Regulatorisk status RUO
Endotoksin koncentration <0.1 EU/ μg
Gene Alias CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Fælles navn LIF
Gen symbol Lif
Biologisk aktivitet Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Indhold og opbevaring -20°C
Udtrykssystem E. coli
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 98% by SDS-PAGE gel and HPLC analyses.
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