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Invitrogen™ Human LAG-3 (CD223) Fc Chimera Recombinant Protein

Artikelnummer. 17986261
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17986261 500 μg
17965861 50 μg
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Artikelnummer. 17986261 Leverandør Invitrogen™ Leverandørnr. RP88096
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    10450.00 DKK
    8778.00 DKK / 500µg
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    16% Slukket
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Forventet forsendelse: 15-12-2026
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Beskrivelse

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (330 μL) be added to the vial to prepare a stock solution of 0.15 mg/mL. Concentration is measured by UV.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P18627
Til brug med (applikation) Binding Assay, Control, ELISA Standard
Format Lyophilized
Formulering PBS with 15% trehalose and no preservative; pH 7.4
Gen-id (Entrez) 3902
Molekylvægt (g/mol) 72.58 kDa
Navn Human LAG-3 (CD223) Fc Chimera
pH-område 7.4
Oprensningsmetode Purified
Mængde 500 μg
Opbevaringskrav -20°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Endotoksin koncentration <1.0 EU/μg
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Fælles navn LAG-3 (CD223)
Gen symbol LAG3
Biologisk aktivitet Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) (at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL)
Produkttype Protein
Konjugeret Unconjugated
Rekombinant Recombinant
Protein tag Fc-tag
Sekvens Human LAG3, amino acids Met1-Leu450 (Accession # NP_002277.4) with a C-terminal mouse IgG1 Fc region
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Aktivitet Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL.
Udtrykssystem HEK293 cells
Form Lyophilized
Renhed eller kvalitetsklasse ≥90% as determined by SDS-PAGE.
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