missing translation for 'onlineSavingsMsg'
Learn More
Gibco™ Human IL-10 Recombinant Protein, PeproTech® Product Code.: 17830513
  1. Home
  2. Products
  3. Recombinant Proteins
  4. Gibco™ Human IL-10 Recombinant Protein, PeproTech®

Gibco™ Human IL-10 Recombinant Protein, PeproTech®

Product Code. p-7246365
100 μg, 100µg
Click to view available options
Quantity:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Unit Size:
100µg
10µg
1mg
250µg
2µg
500µg
50µg
This item is not returnable. View return policy

Product Code. 17830513

Brand: Gibco™ 20010100UG

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P22301
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 3586
Molecular Weight (g/mol) 18.6 kDa
Name Human IL-10
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Common Name IL-10
Gene Symbol IL10
Biological Activity Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
Show More Show Less

Product Suggestions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Gibco™ Human IL-10 Recombinant Protein, PeproTech® >

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.