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Invitrogen™ Human IL-1 beta, Recombinant Protein
E. coli Recombinant Protein
520.00 DKK - 2245.00 DKK
Specifications
For Use With (Application) | Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot |
---|---|
Storage Requirements | -20°C |
Regulatory Status | RUO |
Specific Reactivity | Human |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17164183
|
Invitrogen™
A42509 |
50 μg |
2245.00 DKK
50µg |
Estimated Shipment: 30-05-2024 Log in to see stock. |
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17154183
|
Invitrogen™
A42508 |
5 μg |
520.00 DKK
5µg |
In Stock Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
17174193
|
Invitrogen™
A42521 |
5 x 5 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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17144183
|
Invitrogen™
A42507 |
5 x 5 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.Specifications
Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot | |
RUO | |
Unconjugated | |
Lyophilized |
-20°C | |
Human | |
Recombinant | |
≥ 90% |