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Gibco™ Human GM-CSF Recombinant Protein, PeproTech®

Artikelnummer. 17850053
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Mængde:
1 mg
100 μg
20 μg
250 μg
5 μg
50 μg
500 μg
Pakningsstørrelse:
100µg
50µg
Denne vare kan ikke returneres. Se returpolicy

Artikelnummer. 17850053

Brand: Gibco™ 30003100UG

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4160.00 DKK valid until 2025-12-31
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Beskrivelse

Recombinant Protein

Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P04141
Til brug med (applikation) ELISA, Functional Assay, Western Blot
Formulering protein with no preservative
Gen-id (Entrez) 1437
Molekylvægt (g/mol) 14.6 kDa
Navn Human GM-CSF
Mængde 100 μg
Kilde E. coli
Regulatorisk status RUO
Endotoksin koncentration <1 EU/ μg
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Fælles navn GM-CSF
Gen symbol CSF2
Biologisk aktivitet The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Indhold og opbevaring -20°C
Udtrykssystem E. coli
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 98% by SDS-PAGE gel and HPLC analyses.
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