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Gibco™ Human GM-CSF Recombinant Protein

Artikelnummer. 10150813
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
Hver
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Artikelnummer. 10150813

Brand: Gibco™ PHC2011

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Beskrivelse

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-1.0 mg/mL to regain full activity. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P04141
Til brug med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-id (Entrez) 1437
Molekylvægt (g/mol) 14 kDa
Navn Human GM-CSF
Oprensningsmetode Purified
Mængde 100 μg
Opbevaringskrav 4°C
Regulatorisk status RUO
Endotoksin koncentration <0.1 ng/μg
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Fælles navn GM-CSF
Gen symbol CSF2
Biologisk aktivitet ED50 < 0.1 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Indhold og opbevaring 4°C
Klassifikation Carrier-Free
Aktivitet ED50 < 0.1 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Endotoksin niveau <0.1 ng/μg
Forsendelsestilstand Wet Ice
Udtrykssystem E. coli
Protein familie Cytokines & Receptors
Protein form Recombinant, Ligand
Form Lyophilized
Protein undertype GM-CSF, G-CSF, & M-CSF
Forskningskategori Signal Transduction, Oncology, Stem Cell Research, Differentiation, Drug Development
Produktlinje Gibco
Renhed eller kvalitetsklasse >95% by SDS-PAGE
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