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Gibco™ Human GDNF Recombinant Protein, PeproTech®

Artikelnummer. 17874303
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Mængde:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Pakningsstørrelse:
10µg
50µg
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Artikelnummer. 17874303

Brand: Gibco™ 4501050UG

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Beskrivelse

Recombinant Protein

The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P39905
Til brug med (applikation) ELISA, Functional Assay, Western Blot
Formulering protein with no preservative
Gen-id (Entrez) 2668
Molekylvægt (g/mol) 30.4 kDa
Navn Human GDNF
Mængde 50 μg
Kilde E. coli
Regulatorisk status RUO
Endotoksin koncentration <1 EU/ μg
Gene Alias AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Fælles navn GDNF
Gen symbol GDNF
Biologisk aktivitet Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Indhold og opbevaring -20°C
Udtrykssystem E. coli
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 98% by SDS-PAGE gel and HPLC analyses.
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