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Invitrogen™ Human ErbB2 (HER-2) Fc Chimera Recombinant Protein

Artikelnummer. p-200008597
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Mængde:
1 mg
100 μg
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Artikelnummer. 17946331

Brand: Invitrogen™ RP88054

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Beskrivelse

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1695 μL) be added to the vial to prepare a stock solution of 0.83 mg/mL. Concentration is measured by UV.

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P04626
Koncentration 0.25 mg/mL
Til brug med (applikation) Control, Binding Assay, Bioactivity
Format Lyophilized
Formulering PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gen-id (Entrez) 2064
Molekylvægt (g/mol) 96.09 kDa
Navn Human ErbB2 (HER-2) Fc Chimera
pH-område 7.4
Oprensningsmetode Purified
Mængde 100 μg
Opbevaringskrav -20°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Endotoksin koncentration <1.0 EU/μg
Gene Alias avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Fælles navn Her-2 (ErbB2)
Gen symbol ERBB2
Biologisk aktivitet 1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag) (at 2 μg/ml (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.)
Produkttype Protein
Konjugeret Unconjugated
Rekombinant Recombinant
Protein tag Fc-tag
Sekvens Human ErbB2, amino acids Met1-Thr652 (Accession # NP_004439.2) with a C-terminal human IgG1 Fc region
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Aktivitet Immobilized Recombinant Human HER2 / ErbB2 Protein (Fc Tag) (Cat: 10004-H02H) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 10.2-30.8 ng/mL (QC tested).
Udtrykssystem HEK293 cells
Form Lyophilized
Renhed eller kvalitetsklasse ≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.
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