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Gibco™ Human BMP-4, Animal-Free Recombinant Protein, PeproTech®

Artikelnummer. 17873783
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Mængde:
10 μg
100 μg
2 x 500 μg
500 μg
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Artikelnummer. 17873783

Brand: Gibco™ AF12005ET500UG

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Beskrivelse

Recombinant Protein

AF-120-05ET-1MG will be provided as 2 x 500 μg (AF-120-05ET-500UG). PeproTech's E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, and includes a N-terminal Met residue. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P12644
Til brug med (applikation) Control, Bioactivity
Formulering Protein with no preservative
Gen-id (Entrez) 652
Molekylvægt (g/mol) 24.2 kDa
Navn Human BMP-4, Animal-Free
Oprensningsmetode Purified
Mængde 500 μg
Kilde E. coli
Opbevaringskrav -20°C
Regulatorisk status RUO
Endotoksin koncentration <0.1 EU/μg
Gene Alias BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Fælles navn BMP4
Gen symbol BMP4
Biologisk aktivitet Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml
Produkttype Protein
Konjugeret Unconjugated
Rekombinant Recombinant
Sekvens MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
Indhold og opbevaring -20°C
Aktivitet Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
Udtrykssystem E. coli
Form Lyophilized
Renhed eller kvalitetsklasse ≥ 98% by SDS-PAGE gel and HPLC analyses.
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