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Invitrogen™ Human B7-1 (CD80) His-tag Recombinant Protein
Recombinant Protein
1618.00 DKK - 13215.00 DKK
Specifications
| Accession Number | P33681 |
|---|---|
| For Use With (Application) | ELISA |
| Format | Lyophilized |
| Formulation | PBS with 0.01% mannitol, 0.01% Tween 80, 5-8% trehalose and no preservative; pH 7.4 |
| Gene ID (Entrez) | 941 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17935911
|
Invitrogen™
RP88023 |
100 μg |
1618.00 DKK
100µg |
Estimated Shipment: 18-06-2024 Log in to see stock. |
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|
17976201
|
Invitrogen™
RP88024 |
1 mg |
13215.00 DKK
1mg |
Estimated Shipment: 18-06-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.Specifications
| P33681 | |
| Lyophilized | |
| 941 | |
| CD80 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| <1.0 EU/ μg | |
| CD80 | |
| Human | |
| Recombinant | |
| Measured by its binding ability in a functional ELISA. Immobilized B7-1 Protein, Human, Recombinant (His Tag) (at 2 μg/ml (100 μL/well) can bind CTLA-4 Protein, Human, Recombinant (His and hFc Tag) . The EC50 of of CTLA-4 (His and hFc Tag) is 35-80 ng/mL) | |
| >95% as determined by SDS-PAGE. |
| ELISA | |
| PBS with 0.01% mannitol, 0.01% Tween 80, 5-8% trehalose and no preservative; pH 7.4 | |
| 45-48 kDa | |
| SDS-PAGE | |
| RUO | |
| Activation B7-1 antigen; B7; B7 protein; B7.1; B71; B7-1; B7-1 protein; B7-1 protein precursor; BB1; B-lymphocyte activation antigen B7; Cd28l; CD28LG; CD28LG1; CD80; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 anitgen; CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Cd80 molecule; CD80 protein precursor; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; Ly53; Ly-53; MIC17; sCD 80; sCD80; secreted B7-1 protein precursor; soluble CD 80; soluble CD80; T-cell costimulatory molecule; T-cell co-stimulatory protein B7-1; T-lymphocyte activation antigen CD80; TS/A-1; TSA1 | |
| Protein | |
| Unconjugated | |
| Human B7-1, amino acids Met1-Asn242 (Accession # NP_005182.1) with a C-terminal His-tag | |
| HEK293 cells |