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Invitrogen™ Human Activated Protein C Native Protein

Artikelnummer. 11524131
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Mængde:
50 μg
Pakningsstørrelse:
50µg
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Artikelnummer. 11524131

Brand: Invitrogen™ RP43095

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Beskrivelse

Native Protein

RP-43095 contains native human Activated Protein C protein. RP-43095 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P04070
Koncentration 5.5 mg/mL
Til brug med (applikation) Neutralization
Formulering 50% water with 50% glycerol and no preservative
Gen-id (Entrez) 5624
Molekylvægt (g/mol) 56.2 kDa
Navn Human Activated Protein C
Oprensningsmetode SDS-PAGE
Mængde 50 μg
Kilde Human
Opbevaringskrav -20°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias Activation peptide; Anticoagulant protein C; APC; autoprothrombin IIA; Blood coagulation factor XIV; EDQVDPRLIDGK; inactivator of coagulation factors Va, VIII; PC; prepro-protein C; Proc; PROC1; protein C; protein C (inactivator of coagulation factors Va and VIIIa); protein C prepropeptide; protein C, inactivator of coagulation factors Va and VIIIa; THPH3; THPH4; type I protein C; vitamin K-dependent protein C; Vitamin K-dependent protein C heavy chain; Vitamin K-dependent protein C light chain
Fælles navn Protein C
Gen symbol PROC
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Form Liquid
Protein undertype Native
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