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Tocris Bioscience™ HEMTAC 26

Artikelnummer. 30279917
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5 mg
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Artikelnummer.
30279917 5 mg
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Artikelnummer. 30279917 Leverandør Tocris Bioscience™ Leverandørnr. 7940/5

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Beskrivelse

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC50 values are 19 nM and 26 nM; Dmax = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC50 values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G0/G1 phase in B16F10 cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-
CAS 2821803-61-4
Mængde 5 mg
Mål Active Degraders
Molekylær formel C48H53ClN16O4
Renhed 95%
Produkttitel
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