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Tocris Bioscience™ GX 201
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Artikelnummer. 18727476
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Mængde:
10 mg
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18727476 10 mg
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Artikelnummer. 18727476 Leverandør Tocris Bioscience™ Leverandørnr. 7029/10

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Beskrivelse

Potent and selective Nav1.7 blocker; analgesic

GX 201 is a potent and selective Nav1.7 blocker (IC50 = 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ∽10-fold and provides efficacy that persists after the compound has cleared from plasma. Suppresses neuropathic pain in a mouse diabetic neuropathy model. Analgesic.
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Tekniske data

Kemisk navn eller materiale 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide
CAS 1788071-27-1
Mængde 10 mg
Mål Voltage-gated Sodium Channel Blockers
Molekylær formel C25H27ClF4N2O4S
Renhed 0.98
Produkttitel
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