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Tocris Bioscience™ GW 280264X
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Artikelnummer. 18706166
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50 mg
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Artikelnummer. Mængde
18706166 50 mg
18776786 10 mg
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Artikelnummer. 18706166 Leverandør Tocris Bioscience™ Leverandørnr. 7030/50

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Beskrivelse

Potent ADAM10 and ADAM17 inhibitor

GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Phenylmethyl N-[(5 S)-5-[[(2 R,3 S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate
CAS 866924-39-2
Mængde 50 mg
Mål Synthetic Metalloprotease Inhibitors
Molekylær formel C28H41N5O6S
Renhed 0.98
Produkttitel
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